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Sunday sees the initial Wear-Tyne derby after 2024, but which side will celebrate – the Black Cats or Newcastle?
"For most of last season, you couldn't have imagined the Wearside club getting promoted and challenging with Eddie Howe's Newcastle, let alone being above them in the table," commented pundit Chris Sutton.
"It is very different now, and the way Sunderland play convinces me they've got a genuine opportunity."
Sutton is making scoreline guesses for all 380 Premier League games this season, against AI, fans and a variety of guests.
For week 16, he takes on England Gaming star Daniel 'Stingray' Ray.
Ray is vying for victory for the national gaming squad – the Football Association's recognised esports team – at the EA Sports FC European esports championship finals tournament, which is being held at Twickenham Stadium on Saturday.
The action will be streamed on Uefa's YouTube, Instagram Live and TikTok channels, as well as the official Twitch channel and YouTube and England's Twitch.
Are you in alignment with their predictions? Feel free to submit your own guesses below.
The most commonly selected scoreline picked for each game is featured in the leaderboards at the end of this page.
Getting the win/draw/loss right (selecting a win, draw or defeat) is worth ten points. The exact score earns 40 points.
Ray, who represents Gen City and Manchester City as well as England, is entering the fray at the eEuros finals after getting through the preliminary stage.
The final eight competitors will play for their countries at the finals in a knockout format, vying for a substantial cash prize and a prestigious spot in the world finals play-offs, with the Danish representative Anders Vejrgang defending the title he won last year.
"I am feeling really good for it," Ray remarked. "I've got a really good coach alongside me and practice has been going well.
"It's always an honour to play for your country. Of course when you are younger, you dream about doing it as an actual footballer, but when you pursue a career in this field and there is an chance to represent England, donning the national jersey is something incredible.
"I beat Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd not previously defeated him in a tournament before.
"I believe he is the number one in the world so beating him in a tournament like this just gives you a crazy boost of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
Chelsea were outstanding against Arsenal at the end of November, when they secured a point after going down to 10 men, and I was thinking they've turned a corner, they could possibly be challengers for the crown.
However, since that game, however, they were overpowered by Leeds, looked uninspired against Bournemouth and this week got turned over by Atalanta in the Champions League.
So manager Enzo Maresca desperately requires a win here to get back on track, but it is a tough ask because the Merseyside club are such a threatening team.
Kiernan Dewsbury-Hall and Iliman Ndiaye are playing exceptionally and Everton have got a bit of momentum at the moment.
Current evidence suggests you would probably back the visitors, while the most logical prediction would probably be a draw, but I'm going against logic.
Chelsea haven't given me any compelling evidence to back them recently, but I just have a gut instinct they will emerge victorious because they are at home and they are in need of three points.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be fascinating to see what we get from Liverpool.
I am really pleased for Reds boss Arne Slot to get such a crucial result at Inter Milan on Tuesday after all the controversy with Mohamed Salah this week.
Slot should not have to put up with that distraction. I know Salah has been a legend for the club but essentially Slot just wants to win games and there is no ulterior motive in his team selection.
They changed their formation against Inter and went with a midfield diamond and two up top.
Everyone is going to be talking about whether Salah is back for this game, but the only way he is going to be brought back into the fold is if he says sorry.
Slot's attention will be on winning this game, but it is a challenging encounter.
You could argue it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are defensively susceptible too.
The Merseysiders need to get back to winning consistently, but I am not sure how much their exertions at the San Siro will have drained them.
I've selected a couple of Brighton players in my FPL team, so they will likely do poorly - but I do fancy them to get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
Sunderland have had the week off while Newcastle had to work so hard against Bayer Leverkusen on Wednesday, only to be pegged back late on.
Apart from their excellent performance against Everton a couple of weeks ago, Newcastle's away form has been inconsistent, particularly straight after they've played in the Champions League.
The pattern suggests that tendency to continue on Sunday, and their lack of freshness is likely to be a key element in how this game goes because of Sunderland's energetic style.
Their match against Arsenal demonstrated how incessant Regis le Bris's side are. They dominated the Gunners, and it was amazing to watch.
Everyone talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been brilliant, but Noah Sadiki, who plays alongside him, has also been one of the signings of the season and deserves some attention too.
This promises to be this being the best game|most exciting fixture